Retinoic Acid Receptor beta Antikörper

Produktnummer ABIN271806

Produktdetails anti-Retinoic Acid Receptor beta Antikörper

Target: Retinoic Acid Receptor beta (RARB) (Retinoic Acid Receptor, beta (RARB))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Retinoic Acid Receptor beta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This Antibody detects endogenous levels of Retinoic Acid Receptor beta protein. (region surrounding Leu359)

Kreuzreaktivität (Details): Species reactivity (tested):Human and Mouse.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: PBS, pH 7.2, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Retinoic Acid Receptor beta

Target: Retinoic Acid Receptor beta (RARB) (Retinoic Acid Receptor, beta (RARB))

Andere Bezeichnung: RAR-beta / RARB (RARB Produkte)

Synonyme: RARB antikoerper, nRARs antikoerper, HAP antikoerper, NR1B2 antikoerper, RRB2 antikoerper, A830025K23 antikoerper, Hap antikoerper, Nr1b2 antikoerper, RARbeta2 antikoerper, RARBETA antikoerper, retinoic acid receptor beta antikoerper, retinoic acid receptor, beta antikoerper, RARB antikoerper, Rarb antikoerper

Hintergrund: Retinoids are metabolites of vitamin A (retinol) that are important signaling molecules during vertebrate development and tissue differentiation. Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are nuclear transcription factors that modulate the effects of retinoids (RA) on gene expression. Most retinoid forms (including all trans RA, 9-cis RA, 4oxo RA and 3,4 dihydro RA) activate RAR family members, whereas RXR family members are activated by 9-cis-RA only. RA binds RARs, inducing a change in receptor configuration that allows DNA binding and increased gene transcription from specific genes to occur. RAR family members, which include RARα, RARβ and RARγ, belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. Retinoid receptor expression is tissue specific, the skin expresses RARγ and RXRα. The expression of RARγ and RXRβ was somewhat decreased in lung cancers. The human RARγ gene maps to chromosome 12q13.Synonyms: HAP, HBV-activated protein, NR1B2, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon, Retinoic acid receptor beta

Molekulargewicht: approx. 50 kDa

Gen-ID: 5915

NCBI Accession: NP_057236

UniProt: P10826

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway