ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
OCT1 antikoerper, OTF1 antikoerper, oct-1B antikoerper, POU2F1 antikoerper, 2810482H01Rik antikoerper, NF-A1 antikoerper, Oct-1 antikoerper, Oct1 antikoerper, Otf-1 antikoerper, Otf1 antikoerper, chOCT-1 antikoerper, oct-1 antikoerper, oct1 antikoerper, pou2f1r antikoerper, fc07d06 antikoerper, wu:fc07d06 antikoerper, zgc:158360 antikoerper, POU class 2 homeobox 1 antikoerper, POU domain, class 2, transcription factor 1 antikoerper, POU class 2 homeobox 1 S homeolog antikoerper, POU class 2 homeobox 1b antikoerper, POU2F1 antikoerper, Pou2f1 antikoerper, pou2f1.S antikoerper, pou2f1b antikoerper
Hintergrund
Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs and other xenobiotics. The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT3, also known as extraneuronal monoamine transporter, is widely expressed in different regions of the brain including the hippocampus, cerebellum and cerebral cortex. OCT3 mediates the uptake of several neuroactive agents, including dopamine, and may play an important role in the disposition of neurotransmitters and cationic neurotoxins in the brain. The genes encoding human OCT1-3 map to a conserved cluster at chromosome 6q26-q27.Synonyms: NF-A1, OTF1, Oct-1, Octamer-binding protein 1, Octamer-binding transcription factor 1, Otf-1, POU domain class 2 transcription factor 1