TCRIM antikoerper, TRIM antikoerper, C030046M14Rik antikoerper, Tcrim antikoerper, Trim antikoerper, T cell receptor associated transmembrane adaptor 1 antikoerper, T-cell receptor associated transmembrane adaptor 1 antikoerper, TRAT1 antikoerper, Trat1 antikoerper
Hintergrund
TRIM is a 30 kD disulfide-linked protein also known as T cell receptor interacting molecule. TRIM is a type III membrane protein containing a very short extracellular domain (8 amino acids). TRIM is highly expressed in T cells with some expression also observed in NK cells. TRIM is a signaling adaptor molecule that links extracellular and intracellular signaling. The TRIM protein is phosphorylated by Src kinases and associates with the PI3K regulatory subunit α after phosphorylation. TRIM has also been shown to associate with TCRα, β, and ζ. The TRIM-4 monoclonal antibody recognizes human TRIM and has been shown to be useful for Western blotting, intracellular staining by flow cytometry, and immunofluorescence staining.