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LCK Antikörper (Alexa Fluor 647)
LCK
Reaktivität: Human
FACS
Wirt: Maus
Monoclonal
Lck-01
Alexa Fluor 647
Produktnummer ABIN2657221
Produktdetails anti-LCK Antikörper (Alexa Fluor 647)
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Target
Alle LCK Antikörper anzeigen
LCK
(Lymphocyte-Specific Protein tyrosine Kinase (LCK))
Reaktivität
Alle Reaktivitäten für LCK Antikörper
Human
Wirt
Alle Wirte für LCK Antikörper
Maus
Klonalität
Alle Klonalitäten für LCK Antikörper
Monoklonal
Konjugat
Alle Konjugate für LCK Antikörper
Dieser LCK Antikörper ist konjugiert mit Alexa Fluor 647
Applikation
Alle Applikationen für LCK Antikörper
Flow Cytometry (FACS)
Aufreinigung
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Klon
Lck-01
Isotyp
IgG1 kappa
Top Product
Discover our top product LCK Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Protect from prolonged exposure to light. Do not freeze.
Lagerung
4 °C
Informationen zur Lagerung
The antibody solution should be stored undiluted between 2°C and 8°C
Details zu LCK
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Target
LCK
(Lymphocyte-Specific Protein tyrosine Kinase (LCK))
Andere Bezeichnung
Lck (LCK Produkte )
Synonyme
zgc:136695 antikoerper, LCK antikoerper, Hck-3 antikoerper, Lsk antikoerper, Lskt antikoerper, p56 antikoerper, p56Lck antikoerper, LSK antikoerper, YT16 antikoerper, p56lck antikoerper, pp58lck antikoerper, P56LCK antikoerper, tkl antikoerper, Lck1 antikoerper, Lcktkr antikoerper, LCK proto-oncogene, Src family tyrosine kinase antikoerper, lymphocyte protein tyrosine kinase antikoerper, lck antikoerper, LCK antikoerper, Lck antikoerper
Hintergrund
Lck is a 56 kD tyrosine protein kinase and a member of the src subfamily that contains both an SH2 and SH3 domain. Alternatively spliced isoforms of Lck have been reported. Lck is a cytoplasmic protein bound to CD4 and CD8 in T cells that participate in antigen-induced T cell activation through phosphorylation of the T cell receptor zeta chain. Lck is activated upon T cell receptor engagement and is involved in the onset of cell cycle progression induced by interleukin-2. Phosphorylation by Csk downregulates the activity of Lck. In addition to CD4 and CD8, Lck has been reported to interact with PI3K through its SH3 domain and tyrosine phosphorylated KHDRBS1/p70 through its SH2 domain. In addition, Lck has been shown to associate with the SAP transmembrane tyrosine phosphatase.
Pathways
T-Zell Rezeptor Signalweg , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Transition Metal Ion Homeostasis , Positive Regulation of Endopeptidase Activity , CXCR4-mediated Signaling Events , Thromboxane A2 Receptor Signaling
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