CLEC10A Antikörper (Alexa Fluor 647)

Produktnummer ABIN2657165

Produktdetails anti-CLEC10A Antikörper (Alexa Fluor 647)

Target: CLEC10A (C-Type Lectin Domain Family 10, Member A (CLEC10A))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CLEC10A Antikörper ist konjugiert mit Alexa Fluor 647

Applikation: Immunofluorescence (IF)

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.

Klon: LOM-8-7

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C

Details zu CLEC10A

Target: CLEC10A (C-Type Lectin Domain Family 10, Member A (CLEC10A))

Andere Bezeichnung: CD301a (CLEC10A Produkte)

Synonyme: CLEC10A antikoerper, CD301 antikoerper, CLECSF13 antikoerper, CLECSF14 antikoerper, HML antikoerper, HML2 antikoerper, MGL antikoerper, CD301a antikoerper, M-ASGP-BP-1 antikoerper, Mgl antikoerper, Mgl1 antikoerper, Mgll antikoerper, C-type lectin domain family 10 member A antikoerper, C-type lectin domain containing 10A antikoerper, C-type lectin domain family 10, member A antikoerper, LOC607405 antikoerper, CLEC10A antikoerper, Clec10a antikoerper

Hintergrund: Mouse CD301, also known as macrophage galactose-type C-type lectin, has two homologue genes, CD301a (MGL1) and CD301b (MGL2), while there is only one MGL in human and rat. Mouse CD301a and CD301b are ~42 kD type II transmembrane glycoproteins containing a cytoplasmic domain, a transmembrane domain, a neck domain, and a carbohydrate recognition domain (CRD) within each molecule. CD301a is mainly expressed on a subset of macrophages and immature dendritic cells (DCs). CD301b is mainly found on conventional DCs. Although CD301a and CD301b share high amino acid sequence homology (92 % for the intact sequence and 80 % for the CRD), they display different carbohydrate specificities. CD301a was found to be highly specific for Lewis X and Lewis A structures, whereas CD301b, more similar to the human MGL, recognizes N-actetylgalactosamine (GalNAc) and galactose, including the O-linked Tn-antigen, TF-antigen, and core 2. So far, CD301a has been reported to be involved in recognition and endocytosis of glycoproteins with terminal Gal/GalNAc moieties. This contributes to defense against tumor cell metastasis, tissue remodeling, and clearance of apoptotic cells in embryos. CD301b is involved in the internalization of soluble polyacrylamide polymers (PAA) with α-GalNAc residues (GalNAc-PAA) in bone marrow derived dendritic cells.