GFRA1 Antikörper

Produktnummer ABIN265434

Produktdetails anti-GFRA1 Antikörper

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFRA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of GFR alpha-1 protein. (region surrounding Lys90)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 1000approx. 1: 20000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GFRA1

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Andere Bezeichnung: GFRA1 / GDNFR-alpha (GFRA1 Produkte)

Synonyme: gdnfr antikoerper, ret1l antikoerper, retl1 antikoerper, trnr1 antikoerper, gdnfra antikoerper, MGC122616 antikoerper, gfr-alpha-1 antikoerper, GDNFR antikoerper, GDNFRA antikoerper, GFR-ALPHA-1 antikoerper, RET1L antikoerper, RETL1 antikoerper, TRNR1 antikoerper, GDNFRALPHA antikoerper, GFRA1 antikoerper, AU042498 antikoerper, gfralpha1a antikoerper, zgc:110129 antikoerper, GDNF family receptor alpha 1 antikoerper, glial cell line derived neurotrophic factor family receptor alpha 1 antikoerper, gdnf family receptor alpha 1a antikoerper, gfra1 antikoerper, GFRA1 antikoerper, Gfra1 antikoerper, gfra1a antikoerper

Hintergrund: Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGFβ superfamily of growth factors. Three receptors for these factors, GFRα-1 (also designated GDNFR-α, RETL1 or TrnR-1), GFRα-2 (also designated GDNFR-β, RETL2, NTNR-α or TrnR-2) and GFRα-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFRα-1 and GFRα-2 have been shown to mediate the GDNF-dependent and NTN-dependent phosphorylation and activation of the tyrosine kinase Ret. GFRα-3 is expressed only during development.Synonyms: GDNF family receptor alpha-1, GDNF receptor alpha, GDNFRA, GFR-alpha-1, RET ligand 1, RETL1, TGF-beta-related neurotrophic factor receptor 1, TRNR1

Molekulargewicht: approx. 51 kDa

Gen-ID: 2674

NCBI Accession: NP_005255

UniProt: P56159