Fibrillin 1 Antikörper

Produktnummer ABIN265420

Produktdetails anti-Fibrillin 1 Antikörper

Target: Fibrillin 1 (FBN1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Fibrillin 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Fibrillin-1 protein. (region surrounding asn2843)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/40000-1/60000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-Fibrillin 1 Antikörper (ABIN265420)

Bell, Gendron, Anderson, Flatow, Andarawis-Puri: "A potential new role for myofibroblasts in remodeling of sub-rupture fatigue tendon injuries by exercise." in: Scientific reports, Vol. 8, Issue 1, pp. 8933, (2018) (PubMed).

Details zu Fibrillin 1

Target: Fibrillin 1 (FBN1)

Andere Bezeichnung: Fibrillin-1 (FBN1 Produkte)

Synonyme: FBN1 antikoerper, ACMICD antikoerper, ECTOL1 antikoerper, FBN antikoerper, GPHYSD2 antikoerper, MASS antikoerper, MFS1 antikoerper, OCTD antikoerper, SGS antikoerper, SSKS antikoerper, WMS antikoerper, WMS2 antikoerper, AI536462 antikoerper, B430209H23 antikoerper, Fib-1 antikoerper, Tsk antikoerper, fibrillin 1 antikoerper, FBN1 antikoerper, Fbn1 antikoerper

Hintergrund: The fibrillin family of proteins, including fibrillin-1 (FBN1) and fibrillin-2 (FBN2), are integral components of a distinct subset of extracellular microfibrils. Microfibrils are found in elastic tissues where they facilitate elastic fiber formation and in nonelastic tissue where they support the association of the epithelial cells with the interstitial matrix. Characteristic of the fibrillin proteins are the epidermal growth factor (EGF)-like motifs, which contain a consensus sequence for calcium binding. This calcium association may be critical for protein-protein interactions and stabilization of the microfibrils. Mutations of the FBN1 gene have been shown to result in Marfan syndrome, a disease characterized by abnormal synthesis, secretion and matrix deposition of fibrillin. FBN2 is also linked to a rare, yet similiar, skeletal disorder, congenital contractural arachnodactyly.Synonyms: FBN, FBN1

Gen-ID: 2200

NCBI Accession: NP_000129

UniProt: P35555

Pathways: Maintenance of Protein Location, SARS-CoV-2 Protein Interaktom