Claudin 5 Antikörper

Produktnummer ABIN265364

Produktdetails anti-Claudin 5 Antikörper

Target: Claudin 5 (CLDN5)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Claudin 5 protein. (region surrounding Ser201)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: ELISA: 1/40000approx. 1/60000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200. Immunofluorescence: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Claudin 5

Target: Claudin 5 (CLDN5)

Andere Bezeichnung: Claudin-5 / CLDN5 (CLDN5 Produkte)

Synonyme: AWAL antikoerper, BEC1 antikoerper, CPETRL1 antikoerper, TMVCF antikoerper, cld5 antikoerper, awal antikoerper, bec1 antikoerper, claudin-5 antikoerper, cpetrl1 antikoerper, tmvcf antikoerper, AI854493 antikoerper, MBEC1 antikoerper, Tmvcf antikoerper, cldn5 antikoerper, zgc:85723 antikoerper, zgc:103419 antikoerper, claudin 5 antikoerper, Claudin-5 antikoerper, claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) antikoerper, claudin 5a antikoerper, claudin 5b antikoerper, claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) L homeolog antikoerper, CLDN5 antikoerper, cld5 antikoerper, cldn5 antikoerper, Cldn5 antikoerper, cldn5a antikoerper, cldn5b antikoerper, cldn5.L antikoerper

Hintergrund: The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-5 is expressed in the endothelial junctions of the rat liver and in junctions of acinar cells of the pancreas. Human claudin-5 is abundantly expressed in adult lung, heart and skeletal muscle and is deleted in patients with velocardiofacial syndrone, which is characterized by cleft palate, facial dysmorphology and conotruncal heart defects.The human claudin-5 gene maps to chromosome 22q11.21.Synonyms: AWAL, Bec1, Brain endothelial cell clone 1 protein, Lung-specific membrane protein, TMDVCF, TMVCF, Transmembrane protein deleted in VCFS

Molekulargewicht: approx. 23 kDa

Gen-ID: 7122

NCBI Accession: NP_001124333

UniProt: O00501

Pathways: Hepatitis C