Netrin 1 Antikörper

Produktnummer ABIN265184

Produktdetails anti-Netrin 1 Antikörper

Target: Netrin 1 (NTN1)

Reaktivität: Human, Maus, Ratte, Affe, Rind (Kuh), Cat

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Netrin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects NTN1. Tested on MDCKII cell lysates.

Aufreinigung: Purified

Immunogen: Synthetic peptide derived from the human Netrin 1 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot (0.5-2 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Details zu Netrin 1

Target: Netrin 1 (NTN1)

Andere Bezeichnung: Netrin-1 (NTN1 Produkte)

Synonyme: ntn1-A antikoerper, Netrin-1 antikoerper, NTN1 antikoerper, unc-6 antikoerper, MGC147073 antikoerper, NTN1L antikoerper, AI561871 antikoerper, BC019633 antikoerper, netrin-1 antikoerper, netrin 1 L homeolog antikoerper, netrin 1 antikoerper, ntn1.L antikoerper, NTN1 antikoerper, ntn1 antikoerper, Ntn1 antikoerper

Hintergrund: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis. Netrin 1's main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.Synonyms: NTN1, NTN1L

Gen-ID: 9423

NCBI Accession: NP_004813

UniProt: O95631

Pathways: Regulation of Cell Size