PPAPDC2 Antikörper

Produktnummer ABIN265121

Produktdetails anti-PPAPDC2 Antikörper

Target: PPAPDC2 (Phosphatidic Acid Phosphatase Type 2 Domain Containing 2 (PPAPDC2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPAPDC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts to Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2).

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide derived from human phosphatidic acid phosphatase type 2 domain containing 2 (PPAPDC2)

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 400 - 1: 800. Positive Control: Testis.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Ship on gel ice. Store (in aliquots) at -20 °C only.

Details zu PPAPDC2

Target: PPAPDC2 (Phosphatidic Acid Phosphatase Type 2 Domain Containing 2 (PPAPDC2))

Andere Bezeichnung: PPAPDC2 (PPAPDC2 Produkte)

Synonyme: PPAPDC2 antikoerper, PDP1 antikoerper, PSDP antikoerper, bA6J24.6 antikoerper, 4932443D16Rik antikoerper, phospholipid phosphatase 6 antikoerper, PLPP6 antikoerper, plpp6 antikoerper, Plpp6 antikoerper

Hintergrund: Upon cell activation Presqualene diphosphate (PSDP)2, a bioactive lipid, rapidly remodels to presqualene monophosphate (PSMP). A newly identified and characterized phosphatase (phosphatidic acid phosphatase domain containing 2 (PPAPDC2)) has recent,y been shown to convert PSDP to PSMP. Unlike the related polyisoprenyl phosphate farnesyl diphosphate (FDP), PSDP has been shown not to be a substrate for type 2 lipid phosphate phosphohydrolases. PSDP phosphatase activity has been identified in activated human neutrophil (PMN) extracts. Recombinant PPAPDC2 displays diphosphate phosphatase activity with substrate preference for PSDP > FDP phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and optimal at pH 7.0 - 8.0. PPAPDC2 mRNA has been detected in human PMN, and is widely expressed in human tissues. PPAPDC2 expressed in human PMN is first lipid phosphate phosphohydrolase identified for PSDP. The regulation of this enzymes activity has important implications for PMN activation in innate immunity.Synonyms: PPAP2 domain-containing protein 2, Phosphatidic acid phosphatase type 2 domain-containing protein 2, Presqualene diphosphate phosphatase

Gen-ID: 403313

NCBI Accession: NP_982278

UniProt: Q8IY26