SLA Antikörper
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- Target Alle SLA Antikörper anzeigen
- SLA (Src-Like-Adaptor (SLA))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SLA Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- This antibody reacts to SLA.
- Aufreinigung
- Purified
- Immunogen
- Synthetic peptide derived from the human SLAP1 protein.
- Isotyp
- IgG
- Top Product
- Discover our top product SLA Primärantikörper
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- Applikationshinweise
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Western Blot: 5 - 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- Phosphate buffered saline with 0.08 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
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- Target
- SLA (Src-Like-Adaptor (SLA))
- Andere Bezeichnung
- SLA (SLA Produkte)
- Synonyme
- SLA1 antikoerper, SLAP antikoerper, src-like-adapter antikoerper, SLA antikoerper, Slap1 antikoerper, Slap antikoerper, Slap-1 antikoerper, Src like adaptor antikoerper, Src-like-adaptor antikoerper, src-like adaptor antikoerper, SLA antikoerper, Sla antikoerper
- Hintergrund
- Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Interacts with EPHA2, VAV1, LCP2 and PDGFRB. The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization. Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.Synonyms: SLAP, SLAP-1, SLAP1, Src-like-adapter, Src-like-adapter protein 1
- Gen-ID
- 6503
- NCBI Accession
- NP_001039021
- UniProt
- Q13239
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