SLA Antikörper

Produktnummer ABIN265047

Produktdetails anti-SLA Antikörper

Target: SLA (Src-Like-Adaptor (SLA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts to SLA.

Aufreinigung: Purified

Immunogen: Synthetic peptide derived from the human SLAP1 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 5 - 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu SLA

Target: SLA (Src-Like-Adaptor (SLA))

Andere Bezeichnung: SLA (SLA Produkte)

Synonyme: SLA1 antikoerper, SLAP antikoerper, src-like-adapter antikoerper, SLA antikoerper, Slap1 antikoerper, Slap antikoerper, Slap-1 antikoerper, Src like adaptor antikoerper, Src-like-adaptor antikoerper, src-like adaptor antikoerper, SLA antikoerper, Sla antikoerper

Hintergrund: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Interacts with EPHA2, VAV1, LCP2 and PDGFRB. The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization. Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.Synonyms: SLAP, SLAP-1, SLAP1, Src-like-adapter, Src-like-adapter protein 1

Gen-ID: 6503

NCBI Accession: NP_001039021

UniProt: Q13239