CACNG4 Antikörper
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- Target Alle CACNG4 Antikörper anzeigen
- CACNG4 (Calcium Channel, Voltage-Dependent, gamma Subunit 4 (CACNG4))
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Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CACNG4 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- This antibody reacts to CACNG4.
- Aufreinigung
- Purified
- Immunogen
- Synthetic peptide derived from the rat calcium channel gamma4 subunit conjugated to KLH
- Isotyp
- IgG
- Top Product
- Discover our top product CACNG4 Primärantikörper
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- Applikationshinweise
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Western Blot: 5- 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- Phosphate buffered saline with 0.08 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
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- Target
- CACNG4 (Calcium Channel, Voltage-Dependent, gamma Subunit 4 (CACNG4))
- Andere Bezeichnung
- CACNG4 (CACNG4 Produkte)
- Synonyme
- CACNG4 antikoerper, AI413107 antikoerper, AW491861 antikoerper, calcium voltage-gated channel auxiliary subunit gamma 4 antikoerper, calcium channel, voltage-dependent, gamma subunit 4 antikoerper, CACNG4 antikoerper, Cacng4 antikoerper
- Hintergrund
- Voltage-dependent calcium channels (VDCCs) are large (>400 kDa) heteromers which contain, minimally, three core subunits alpha1, alpha2/delta, beta in a 1:1:1 stoichiometry1. Expression of VDCC gene products in Xenopus oocytes, or transfected cells shows that the alpha1 subunits contain the ion channel pore while the auxiliary alpha2/delta and beta subunits confer optimal cell surface expression and channel kinetics. Until recently, the only exception to the above paradigm was the skeletal muscle VDCC, which, in addition to the alpha1, alpha2/delta, beta core motif, also has an additional tightly associated integral membrane glycoprotein subunit termed gamma 1. Upon co-expression with the alpha1.1, alpha2/delta1, beta1a subunits of the skeletal muscle VDCC, gamma subunits alter the peak currents, and the kinetics of channel activation and inactivation with the overall effect being a normalisation of currents to those resembling the endogenous channel. Together, these results suggest that gamma subunits modulate skeletal muscle VDCCs by stabilising their conformation. The gamma 4 subunit is specifically localized in the brain, with the gamma 2 and gamma 3 subunits. It shares >60 % sequence homology with the gamma 2 and gamma 3 subunits and ~25 % sequence homology with the gamma 1 and gamma 5 subunits.Synonyms: Neuronal voltage-gated calcium channel gamma-4 subunit, Voltage-dependent calcium channel gamma-4 subunit
- Gen-ID
- 27092
- NCBI Accession
- NP_055220
- UniProt
- Q9UBN1
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