CYP3A5 Antikörper (C-Term)

Produktnummer ABIN264500

Produktdetails anti-CYP3A5 Antikörper

Target: CYP3A5 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (CYP3A5))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CYP3A5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This antibody reacts to Cytochrome P450 3A5.

Produktmerkmale: Synonyms: Cytochrome P450 3A5, Cytochrome P450-PCN3, Cytochrome P450 HLp2

Aufreinigung: Purified

Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with asynthetic peptide derived from the Cterminus of the human CYP3A5 protein and mousemyeloma Ag8563 cells.

Klon: F18 P3 B6

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections: 1 - 5 μg/mL. When used in conjunction with CYP3A7 (Cat. No. ABIN264501), can differentiate betweenthe CYP3A family members, 3A5 and 3A7. Positive Control: Squamous oesophagus cancer.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CYP3A5

Target: CYP3A5 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (CYP3A5))

Andere Bezeichnung: CYP3A5 (CYP3A5 Produkte)

Synonyme: CP35 antikoerper, CYPIIIA5 antikoerper, P450PCN3 antikoerper, PCN3 antikoerper, cytochrome P450 family 3 subfamily A member 5 antikoerper, CYP3A5 antikoerper

Hintergrund: CYP3A genes encode monooxygenases, enzymes which catalyze drug metabolism and the synthesis of cholesterol, steroids and other lipids. CYP3A (cytochrome P450, family 3, subfamily A), the most abundant p450 enzyme in human liver, is responsible for the metabolism of more than 50 % of all clinical drugs. CYP3A members localize in organs that associate with drug disposition, including the liver, gastrointestinal tract and kidney. The CYP3A cluster consists of four genes: CYP3A43, CYP3A4, CYP3A7 and CYP3A5, and two pseudogenes: CYP3A5P1 and CYP3A5P2. The CYP3A cluster maps to gene locus 7q21.3-q22.1.Synonyms: Cytochrome P450 3A5, Cytochrome P450 HLp2, Cytochrome P450-PCN3

Gen-ID: 1577

UniProt: P20815

Pathways: Steroid Hormone Biosynthesis