TNC Antikörper

Produktnummer ABIN2629348

Produktdetails anti-TNC Antikörper

Target: TNC (Tenascin C (TNC))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TNC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: A 265 kD protein. Tenascin C contains an extensive number of potential glycosylation sites, which may explain its migration at a higher molecular weight than predicted. Human tonsilar tissue can be used as a positive control in immunocytochemistry and immunohistochemistry.

Aufreinigung: Purified

Immunogen: T2H5 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a BALB/c mouse immunized with full length native tenascin protein purified from a homogenate of a human mammary tumor specimen.

Type of Immunogen: Purified protein

Klon: T2H5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Approved: ICC, IHC, IHC-Fr, IHC-P, IP, WB

Usage: Tenascin is a high molecular weight, multifunctional, extracellular matrix glycoprotein expressed in association with mesenchymal-epithelial interactions during development. It has been described under a variety of names, i. e. cytotactin, hexabrachion protein, J1, myotendinous antigen and glioma mesenchymal extracellular matrix. In undifferentiated tumors it is also detectable in the neovasculature and stroma. The tenascin molecule is a disulfide-linked hexamer. The expression of tenascin is associated with development and growth, both normal and pathological, whereas the distribution in normal adult tissue is restricted. For example, this extracellular matrix protein is implicated in guidance of migrating neurons as well as axons during neural development as well as neuronal regeneration. In in vitro studies it promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. The cellular ligands for tenascin include integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS, 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C, or in small aliquots at -20°C.

Details zu TNC

Target: TNC (Tenascin C (TNC))

Andere Bezeichnung: TNC / Tenascin C (TNC Produkte)

Synonyme: tn antikoerper, 150-225 antikoerper, GMEM antikoerper, GP antikoerper, HXB antikoerper, JI antikoerper, TN antikoerper, TN-C antikoerper, AI528729 antikoerper, C130033P17Rik antikoerper, Hxb antikoerper, Ten antikoerper, cytotactin antikoerper, tenascin-C antikoerper, P230 antikoerper, tenc antikoerper, wu:fk04d02 antikoerper, tenascin C L homeolog antikoerper, tenascin C antikoerper, tnc.L antikoerper, TNC antikoerper, MCYG_00667 antikoerper, tnc antikoerper, Tnc antikoerper

Hintergrund: Name/Gene ID: TNC
Family: Fibronectin

Synonyms: TNC, 150-225, Cytotactin, GP, Hexabrachion (tenascin), GMEM, GP 150-225, Miotendinous antigen, Myotendinous antigen, JI, Tenascin, Tenascin C, Neuronectin, Tenascin-C isoform 14/AD1/16, TN-C, Hexabrachion, HXB, Tenascin-C, TN

Gen-ID: 3371

Pathways: Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development