183ActI antikoerper, CD158J antikoerper, CD158b antikoerper, NKAT5 antikoerper, cl-49 antikoerper, killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 antikoerper, KIR2DS2 antikoerper
Hintergrund
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells (1). The KIR proteins are classified by the number of extracellular immunoglobulin domains and by whether they have a long (L) or short (S) cytoplasmic domain (2,3). KIR proteins are thought to play an important role in regulation of the immune response (3). KIR2DS2 downregulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells and is a receptor on natural killer (NK) cells for HLA-C alleles (3,4).