HSP90B2P Antikörper (AA 289-300)

Produktnummer ABIN2470237

Produktdetails anti-HSP90B2P Antikörper

Target: HSP90B2P (Heat Shock Protein 90kDa beta (Grp94), Member 2, Pseudogene (HSP90B2P))

Bindungsspezifität: AA 289-300

Reaktivität: Human, Maus, Ratte, Drosophila melanogaster, Affe, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSP90B2P Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Immunoaffinity Chromatography

Immunogen: HSP90B2P antibody was raised against amino acids 289-300 of HSP90B2P (Human).

Anwendungsinformationen

Applikationshinweise: HSP90B2P antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 - 10 μg/mL, immunoprecipitation, and flow cytometry.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store HSP90B2P antibody at 4 °C or -20 °C.

Details zu HSP90B2P

Target: HSP90B2P (Heat Shock Protein 90kDa beta (Grp94), Member 2, Pseudogene (HSP90B2P))

Andere Bezeichnung: HSP90B2P (HSP90B2P Produkte)

Synonyme: GRP94P1 antikoerper, GRP94b antikoerper, HSP antikoerper, HSPCP2 antikoerper, TRA1P1 antikoerper, TRAP1 antikoerper, heat shock protein 90 beta family member 2, pseudogene antikoerper, HSP90B2P antikoerper

Hintergrund: Hsp90 is a member of the heat shock protein 90 family that functions as a molecular chaperone and has ATPase activity. Hsp90 family proteins are highly conserved between isoforms and species. Several signal transduction pathways depend on Hsp90 function including erbB2, steroid hormone receptors (such as androgen, progesterone, glucocorticoid, and aryl-hydrocarbon), and hypoxia sensing (Hif1alpha). Recent reports show that tumor cells are more sensitive to Hsp90 inhibition and that Hsp90 from tumor cells is more sensitive to small molecule inhibitors (eg 17AAG). The mechanism of this differential sensitivity of normal versus tumor Hsp90 is not known (although mutation has been ruled out). One possible mechanism may be differences in post-translational modification of tumor Hsp90. Hsp90 is a cytoplasmic protein that forms a homodimer in vivo, and interacts with TOM34, AHSA1, HDAC6 and SMYD3.

Gen-ID: 3320

UniProt: P07900