TACI Antikörper (AA 116-132)

Produktnummer ABIN2470171

Produktdetails anti-TACI Antikörper

Target: TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))

Bindungsspezifität: AA 116-132

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TACI Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)

Aufreinigung: Protein G Column

Immunogen: TNFRSF13B antibody was raised against amino acids 116 - 132 of TNFRSF13B (Human).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TNFRSF13B antibody can be used in Western Blot starting at 1:1000, immunohistochemistry starting at 5 μg/mL, immunohistochemistry -Pfa starting at 1 μg/mL, and flow cytometry.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.05 % sodium azide and 0.2 % gelatin.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: TNFRSF13B antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.

Details zu TACI

Target: TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))

Andere Bezeichnung: TNFRSF13B (TNFRSF13B Produkte)

Synonyme: CD267 antikoerper, CVID antikoerper, CVID2 antikoerper, RYZN antikoerper, TACI antikoerper, TNFRSF14B antikoerper, TNFRSF13B antikoerper, 1200009E08Rik antikoerper, Taci antikoerper, TNF receptor superfamily member 13B antikoerper, tumor necrosis factor receptor superfamily, member 13b antikoerper, TNFRSF13B antikoerper, Tnfrsf13b antikoerper

Hintergrund: Simultaneously four different laboratories identified a a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 , THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase , BAFF (for B cell activating factor belonging to the TNF family) and BlyS (B lymphocyte stimulator). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The receptor for BlyS/BAFF appears to be expressed predominantly on B cells and activated T cells. Recently two orphan receptors TACI and BCMA (,8) have been shown to be receptors for BlyS/BAFF (6-9). TACI is expressed on B cells and signals through CAML, activating the transcription factors NF-AT, NF-κ,B, and AP-1. TACI is one of three know receptors for BLys. Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-κ,B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

Gen-ID: 23495

UniProt: O14836