SEMA6D Antikörper

Produktnummer ABIN2463280

Produktdetails anti-SEMA6D Antikörper

Target: SEMA6D (Sema Domain, Transmembrane Domain (TM), and Cytoplasmic Domain, (Semaphorin) 6D (SEMA6D))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SEMA6D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SEMA6D.

Anwendungsinformationen

Applikationshinweise: SEMA6D antibody can be used for detection of SEMA6D by ELISA at 1:312500. SEMA6D antibody can be used for detection of SEMA6D by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store SEMA6D antibody at -20 °C.

Details zu SEMA6D

Target: SEMA6D (Sema Domain, Transmembrane Domain (TM), and Cytoplasmic Domain, (Semaphorin) 6D (SEMA6D))

Andere Bezeichnung: SEMA6D (SEMA6D Produkte)

Synonyme: 1110067B02Rik antikoerper, AA409156 antikoerper, D330011G23 antikoerper, Sema6D-1 antikoerper, Sema6D-2 antikoerper, Sema6D-4 antikoerper, Sema6D-5 antikoerper, Sema6D-6 antikoerper, mKIAA1479 antikoerper, wu:fi06a12 antikoerper, wu:fi76a10 antikoerper, zgc:56170 antikoerper, semaphorin 6D antikoerper, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D antikoerper, semaphorin 6D L homeolog antikoerper, SEMA6D antikoerper, Sema6d antikoerper, sema6d antikoerper, sema6d.L antikoerper

Hintergrund: Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphoring domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. SEMA6D is a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Six transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Six transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.

Molekulargewicht: 52 kDa

Gen-ID: 80031

NCBI Accession: NP_079242

UniProt: Q8NFY4

Pathways: Smooth Muscle Cell Migration