UGT1A4 Antikörper

Produktnummer ABIN2463019

Produktdetails anti-UGT1A4 Antikörper

Target: UGT1A4 (UDP Glucuronosyltransferase 1 Family, Polypeptide A4 (UGT1A4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UGT1A4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human UGT1A4.

Anwendungsinformationen

Applikationshinweise: UGT1A4 antibody can be used for detection of UGT1A4 by ELISA at 1:312500. UGT1A4 antibody can be used for detection of UGT1A4 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store UGT1A4 antibody at -20 °C.

Details zu UGT1A4

Target: UGT1A4 (UDP Glucuronosyltransferase 1 Family, Polypeptide A4 (UGT1A4))

Andere Bezeichnung: UGT1A4 (UGT1A4 Produkte)

Synonyme: HUG-BR2 antikoerper, UDPGT antikoerper, UDPGT 1-4 antikoerper, UGT-1D antikoerper, UGT1-04 antikoerper, UGT1.4 antikoerper, UGT1D antikoerper, UGT1 antikoerper, UGT1A4 antikoerper, UDP glucuronosyltransferase family 1 member A4 antikoerper, UDP-glucuronosyltransferase 1-4 antikoerper, UGT1A4 antikoerper, UGT1-4 antikoerper

Hintergrund: UGT1A4 is an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.

Molekulargewicht: 57 kDa

Gen-ID: 54657

NCBI Accession: NP_009051

UniProt: P22310

Pathways: Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha