MRPS12 Antikörper

Produktnummer ABIN2462968

Produktdetails anti-MRPS12 Antikörper

Target: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MRPS12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MRPS12.

Anwendungsinformationen

Applikationshinweise: MRPS12 antibody can be used for detection of MRPS12 by ELISA at 1:1562500. MRPS12 antibody can be used for detection of MRPS12 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store MRPS12 antibody at -20 °C.

Details zu MRPS12

Target: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Andere Bezeichnung: MRPS12 (MRPS12 Produkte)

Synonyme: MPR-S12 antikoerper, MT-RPS12 antikoerper, RPMS12 antikoerper, RPS12 antikoerper, RPSM12 antikoerper, AI327385 antikoerper, Rpms12 antikoerper, rps12 antikoerper, CG7925 antikoerper, Dmel\\CG7925 antikoerper, EG:BACH59J11.1 antikoerper, MRP-S12 antikoerper, MRPS12 antikoerper, S12 antikoerper, Tko antikoerper, l(1)3Ab antikoerper, l(1)tko antikoerper, mRpS12 antikoerper, mt-rps12 antikoerper, MGC64304 antikoerper, GB10531 antikoerper, mitochondrial ribosomal protein S12 antikoerper, technical knockout antikoerper, mitochondrial ribosomal protein S12 L homeolog antikoerper, 40S ribosomal protein S12, mitochondrial antikoerper, putative mitochondrial 37S ribosomal protein MRPS12 antikoerper, fragile site, aphidicolin type, common, fra(6)(p22.2) antikoerper, MRPS12 antikoerper, Mrps12 antikoerper, tko antikoerper, mrps12.L antikoerper, LOC409723 antikoerper, mRpS12 antikoerper, mrps12 antikoerper, CAALFM_C106070WA antikoerper, mrpS12 antikoerper, FRA6C antikoerper

Hintergrund: Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. MRPS12 is the 28S subunit protein that belongs to the ribosomal protein S12P family. The protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics.Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene, all three variants encode the same protein.

Molekulargewicht: 12 kDa

Gen-ID: 6183

NCBI Accession: NP_066930

UniProt: O15235

Pathways: Sensory Perception of Sound