CHRNB2 Antikörper

Produktnummer ABIN2461570

Produktdetails anti-CHRNB2 Antikörper

Target: CHRNB2 (Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHRNB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CHRNB2.

Anwendungsinformationen

Applikationshinweise: CHRNB2 antibody can be used for detection of CHRNB2 by ELISA at 1:312500. CHRNB2 antibody can be used for detection of CHRNB2 by western blot at 5.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store CHRNB2 antibody at -20 °C.

Details zu CHRNB2

Target: CHRNB2 (Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))

Andere Bezeichnung: CHRNB2 (CHRNB2 Produkte)

Synonyme: EFNL3 antikoerper, nAChRB2 antikoerper, NACHRB2 antikoerper, Acrb-2 antikoerper, Acrb2 antikoerper, C030030P04Rik antikoerper, [b]2-nAchR antikoerper, cholinergic receptor nicotinic beta 2 subunit antikoerper, cholinergic receptor nicotinic beta 2 subunit S homeolog antikoerper, cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) antikoerper, CHRNB2 antikoerper, chrnb2.S antikoerper, Chrnb2 antikoerper

Hintergrund: Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.

Molekulargewicht: 57 kDa

Gen-ID: 1141

NCBI Accession: NP_000739

UniProt: P17787

Pathways: Sensory Perception of Sound, Feeding Behaviour