TNNT1 Antikörper

Produktnummer ABIN2458625

Produktdetails anti-TNNT1 Antikörper

Target: TNNT1 (Slow Skeletal Troponin T (TNNT1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNNT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TNNT1.

Anwendungsinformationen

Applikationshinweise: TNNT1 antibody can be used for detection of TNNT1 by ELISA at 1:312500. TNNT1 antibody can be used for detection of TNNT1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store TNNT1 antibody at -20 °C.

Details zu TNNT1

Target: TNNT1 (Slow Skeletal Troponin T (TNNT1))

Andere Bezeichnung: TNNT1 (TNNT1 Produkte)

Synonyme: ANM antikoerper, NEM5 antikoerper, STNT antikoerper, TNT antikoerper, TNTS antikoerper, TNNI1 antikoerper, AW146156 antikoerper, Tnt antikoerper, sTnT antikoerper, ssTnT antikoerper, Fang2 antikoerper, tnTs antikoerper, Tnnt antikoerper, zgc:193831 antikoerper, zgc:193865 antikoerper, troponin T1, slow skeletal type antikoerper, troponin I1, slow skeletal type antikoerper, troponin T1, skeletal, slow antikoerper, troponin T1, slow skeletal type S homeolog antikoerper, troponin T type 1 (skeletal, slow) antikoerper, TNNT1 antikoerper, TNNI1 antikoerper, Tnnt1 antikoerper, tnnt1.S antikoerper, tnnt1 antikoerper

Hintergrund: TNNT1 is a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year.This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 33 kDa

Gen-ID: 7138

NCBI Accession: NP_003274

UniProt: P13805