HSBP1 Antikörper

Produktnummer ABIN2458158

Produktdetails anti-HSBP1 Antikörper

Target: HSBP1 (Heat Shock Factor Binding Protein 1 (HSBP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSBP1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HSBP1.

Anwendungsinformationen

Applikationshinweise: HSBP1 antibody can be used for detection of HSBP1 by ELISA at 1:312500. HSBP1 antibody can be used for detection of HSBP1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store HSBP1 antibody at -20 °C.

Details zu HSBP1

Target: HSBP1 (Heat Shock Factor Binding Protein 1 (HSBP1))

Andere Bezeichnung: HSBP1 (HSBP1 Produkte)

Synonyme: HSBP1 antikoerper, npc-a-13 antikoerper, NPC-A-13 antikoerper, hsbp1 antikoerper, hsbp1a antikoerper, 0610007A03Rik antikoerper, AA408769 antikoerper, Hsp25 antikoerper, zgc:73224 antikoerper, heat shock factor binding protein 1 like 1 antikoerper, heat shock factor binding protein 1 antikoerper, Heat shock factor binding protein 1 antikoerper, heat shock factor binding protein 1 S homeolog antikoerper, heat shock factor binding protein 1 L homeolog antikoerper, heat shock factor binding protein 1b antikoerper, HSBP1L1 antikoerper, HSBP1 antikoerper, Bm1_07370 antikoerper, hsbp1.S antikoerper, hsbp1 antikoerper, hsbp1.L antikoerper, Hsbp1 antikoerper, hsbp1b antikoerper

Hintergrund: The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1 (HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1 (HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.

Molekulargewicht: 8 kDa

Gen-ID: 3281

NCBI Accession: NP_001528

UniProt: O75506

Pathways: SARS-CoV-2 Protein Interaktom