HCV Core Protein Antikörper (AA 13-124, AA 369-704) (Biotin)
-
- Target Alle HCV Core Protein (HCV C) Antikörper anzeigen
- HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))
-
Bindungsspezifität
- AA 13-124, AA 369-704
-
Reaktivität
- Hepatitis C Virus (HCV)
-
Wirt
- Maus
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser HCV Core Protein Antikörper ist konjugiert mit Biotin
-
Applikation
- ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
- Spezifität
- Specific to human HCV core antigen of genotype 1b.
- Kreuzreaktivität (Details)
- Not tested in other genotypes.
- Sterilität
- Sterile filtered
- Immunogen
- A part of the core region (nucleotides 369-704, aa 13-124) of HCV C expressed in E. coli
- Klon
- H6-29
- Isotyp
- IgG2a kappa
-
-
- Applikationshinweise
-
1. Western blotting
2. Immunohistochemistry
3. Immunofluorescence staining
4. ELISA - Kommentare
-
Conjugate: Bitin conjugated, [biotin] / [IgG] = 6.6
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 0.7 mg/mL
- Buffer
- PBS, 50 % glycerol
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C
-
-
Molecular virology of hepatitis C virus (HCV): 2006 update." in: International journal of medical sciences, Vol. 3, Issue 2, pp. 29-34, (2006) (PubMed).
: "Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3." in: Virology, Vol. 198, Issue 2, pp. 636-44, (1994) (PubMed).
: "Immunohistochemical detection of hepatitis C virus-infected hepatocytes in chronic liver disease with monoclonal antibodies to core, envelope and NS3 regions of the hepatitis C virus genome." in: Hepatology (Baltimore, Md.), Vol. 16, Issue 2, pp. 306-11, (1992) (PubMed).
: "Structure and organization of the hepatitis C virus genome isolated from human carriers." in: Journal of virology, Vol. 65, Issue 3, pp. 1105-13, (1991) (PubMed).
: "Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 24, pp. 9524-8, (1991) (PubMed).
: "
-
Molecular virology of hepatitis C virus (HCV): 2006 update." in: International journal of medical sciences, Vol. 3, Issue 2, pp. 29-34, (2006) (PubMed).
-
- Target
- HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))
- Andere Bezeichnung
- HCV Core Protein (HCV C Produkte)
- Substanzklasse
- Viral Protein
- Hintergrund
- Hepatitis C virus (HCV) is a small (55-65 nm in size), enveloped, positive sense single-stranded RNA virus in the family Flaviviridae and the principal cause of parenteral non-A, non-B hepatitis. The virus genome consists of a single open reading frame of approximately 9,4 kb which encodes a single polyprotein of about 3,010 amino acids. The polyprotein is processed by host cell and viral proteases into four structural proteins (core, envelope1 and 2, and p7) and six non-structural proteins (NS2, 3, 4a, 4b, 5a, and 5b) necessary for viral replication. HCV core protein is not only a component of nucleocapsid but also has multiple functions and is a pathogenic factor for hepatitis. It also participates in some cellular processes, including transcriptional regulation and cellular transduction. HCV core antigen is used as diagnostic marker for HCV infection.
-