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HMGCS1 Antikörper
HMGCS1
Reaktivität: Human
ELISA, IHC
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN2433131
Produktdetails anti-HMGCS1 Antikörper
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Target
Alle HMGCS1 Antikörper anzeigen
HMGCS1
(3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1))
Reaktivität
Alle Reaktivitäten für HMGCS1 Antikörper
Human
Wirt
Alle Wirte für HMGCS1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für HMGCS1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für HMGCS1 Antikörper
Dieser HMGCS1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für HMGCS1 Antikörper
ELISA, Immunohistochemistry (IHC)
Aufreinigung
Affinity purification
Immunogen
Synthetic peptide of human HMGCS1
Isotyp
IgG
Top Product
Discover our top product HMGCS1 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
IHC 1:50-1:200
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
0.6 mg/mL
Buffer
PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
Konservierungsmittel
Sodium azide
Handhabung
Avoid freeze / thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
Store at -20°C. Avoid freeze / thaw cycles.
Details zu HMGCS1
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Target
HMGCS1
(3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1))
Andere Bezeichnung
HMGCS1 (HMGCS1 Produkte )
Synonyme
HMGCS antikoerper, zgc:56481 antikoerper, B130032C06Rik antikoerper, 3-hydroxy-3-methylglutaryl-CoA synthase 1 antikoerper, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) antikoerper, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 antikoerper, 3-hydroxy-3-methylglutaryl coenzyme A synthase antikoerper, hydroxymethylglutaryl-CoA synthase antikoerper, 3-hydroxy-3-methylglutaryl-CoA synthase antikoerper, hydroxymethylglutaryl coenzyme A synthase antikoerper, 3-hydroxy-3-methylglutaryl-CoA synthase 1 S homeolog antikoerper, HMGCS1 antikoerper, hmgcs1 antikoerper, Hmgcs1 antikoerper, mvaS antikoerper, SAS2432 antikoerper, SZO_RS04705 antikoerper, SEQ_1109 antikoerper, NAEGRDRAFT_77778 antikoerper, hmgcs1.S antikoerper
Hintergrund
HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.
NCBI Accession
NP_001091742
Pathways
Regulation of Lipid Metabolism by PPARalpha
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