Nephrin Antikörper

Produktnummer ABIN2426273

Produktdetails anti-Nephrin Antikörper

Target: Nephrin (NPHS1) (Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nephrin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human NPHS1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:25-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Handhabung: Avoid freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Nephrin

Target: Nephrin (NPHS1) (Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1))

Andere Bezeichnung: NPHS1 (NPHS1 Produkte)

Synonyme: NPHS1 antikoerper, nphs1l antikoerper, nphs1 antikoerper, CNF antikoerper, NPHN antikoerper, nephrin antikoerper, NephrinB antikoerper, NPHS1, nephrin antikoerper, nephrosis 1, congenital, Finnish type (nephrin) antikoerper, NPHS1 nephrin S homeolog antikoerper, nephrin antikoerper, NPHS1 nephrin antikoerper, nephrosis 1, nephrin antikoerper, NPHS1 antikoerper, nphs1 antikoerper, nphs1.S antikoerper, LOC5579127 antikoerper, Nphs1 antikoerper

Hintergrund: CNF,Nephrin,Nephrosis 1 congenital Finnish type,Nephrosis 1,congenital,Finnish type (nephrin),NPHN,NPHN,NPHS 1,Nphs1,Renal glomerulus specific cell adhesion receptor,Renal glomerulus-specific cell adhesion receptor,This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180- kDa protein in lysates of human glomeruli and a 150- kDa protein in transfected COS-7 cell lysates.

Molekulargewicht: Calculated MW: 135 kDa

NCBI Accession: NP_004637

Pathways: Regulation of Actin Filament Polymerization, Skeletal Muscle Fiber Development