Cullin 4A Antikörper

Produktnummer ABIN2425716

Produktdetails anti-Cullin 4A Antikörper

Target: Cullin 4A (CUL4A)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cullin 4A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Antigen affinity purification

Immunogen: Synthetic peptide of human CUL4A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Handhabung: Avoid freeze / thaw cycles.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Store at -20°C (regular) and -80°C (long term).

Details zu Cullin 4A

Target: Cullin 4A (CUL4A)

Andere Bezeichnung: CUL4A (CUL4A Produkte)

Synonyme: zgc:64071 antikoerper, CUL4A antikoerper, 2810470J21Rik antikoerper, AW495282 antikoerper, RGD1563853 antikoerper, cullin 4A antikoerper, CUL4A antikoerper, cul4a antikoerper, Cul4a antikoerper

Hintergrund: CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins.Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication.

Molekulargewicht: Calculated MW: 88 kDa