SRGAP3 Antikörper

Produktnummer ABIN2424201

Produktdetails anti-SRGAP3 Antikörper

Target: SRGAP3 (SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRGAP3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human SRGAP3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:25-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.6 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Handhabung: Avoid freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SRGAP3

Target: SRGAP3 (SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3))

Andere Bezeichnung: SRGAP3 (SRGAP3 Produkte)

Synonyme: AI452337 antikoerper, Arhgap14 antikoerper, D130026O08Rik antikoerper, Gbi antikoerper, MEGAP antikoerper, WRP antikoerper, mKIAA0411 antikoerper, RGD1563152 antikoerper, ARHGAP14 antikoerper, SRGAP2 antikoerper, RGD1566016 antikoerper, srGAP2 antikoerper, fnbp2 antikoerper, srgap2 antikoerper, SLIT-ROBO Rho GTPase activating protein 3 antikoerper, SLIT-ROBO Rho GTPase activating protein 2 antikoerper, SLIT-ROBO Rho GTPase activating protein 2 L homeolog antikoerper, Srgap3 antikoerper, SRGAP3 antikoerper, Srgap2 antikoerper, srgap3 antikoerper, srgap2.L antikoerper

Hintergrund: SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.