TAD antikoerper, cTADS antikoerper, MGC82176 antikoerper, CRTAM antikoerper, CD355 antikoerper, cytotoxic and regulatory T-cell molecule antikoerper, cytotoxic and regulatory T-cell molecule L homeolog antikoerper, cytotoxic and regulatory T cell molecule antikoerper, CRTAM antikoerper, crtam.L antikoerper, Crtam antikoerper
Hintergrund
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A, MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.