Benzo[a]pyrenediol Epoxide Antikörper

Produktnummer ABIN2192144

Produktdetails anti-Benzo[a]pyrenediol Epoxide Antikörper

Target: Benzo[a]pyrenediol Epoxide (BPDE)

Reaktivität: Chemical

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Benzo[a]pyrenediol Epoxide Antikörper ist unkonjugiert

Applikation: Immunoassay (IA), Immunoprecipitation (IP)

Sterilität: 0.2 μm filtered

Klon: 8E11

Anwendungsinformationen

Applikationshinweise: The monoclonal antibody 8E11 can be used for immuno purification and for immuno assays as detector.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-Benzo[a]pyrenediol Epoxide Antikörper (ABIN2192144)

Santella, Gammon, Zhang, Motykiewicz, Young, Hayes, Terry, Schoenberg, Brinton, Bose, Teitelbaum, Hibshoosh: "Immunohistochemical analysis of polycyclic aromatic hydrocarbon-DNA adducts in breast tumor tissue." in: Cancer letters, Vol. 154, Issue 2, pp. 143-9, (2000) (PubMed).

Mumford, Williams, Wilcosky, Everson, Young, Santella: "A sensitive color ELISA for detecting polycyclic aromatic hydrocarbon-DNA adducts in human tissues." in: Mutation research, Vol. 359, Issue 3, pp. 171-7, (1996) (PubMed).

Santella, Lin, Cleveland, Weinstein: "Monoclonal antibodies to DNA modified by a benzo[a]pyrene diol epoxide." in: Carcinogenesis, Vol. 5, Issue 3, pp. 373-7, (1984) (PubMed).

Details zu Benzo[a]pyrenediol Epoxide

Target: Benzo[a]pyrenediol Epoxide (BPDE)

Abstract: BPDE Produkte

Substanzklasse: Chemical

Hintergrund: A number of chemicals, including polycyclic aromatic hydrocarbons (PAHs), have been shown to bind to DNA. This DNA damage can occur both early and late in the malignant process, thereby acting as an initiator and assisting in the progression of tumors. PAHs are released into the environment following incomplete combustion of organic materials. The most common sources of PAHs are from smoking and from consuming broiled or grilled foods. Human exposure to PAHs comes from various occupational, environmental, dietary and medicinal sources. Benzo[a]pyrene is a representitive PAH. Antibodies to benzo[a]pyrenediol-epoxide modified DNA (BPDE-DNA) can be used to identify polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Exposure to this group of compounds is believed to be carcinogenic. The monoclonal antibody 8E11 recognizes free BPDE and DNA adducts.