Ethenoadenosine Antikörper
WB, IP, FACS, IHC (fro), IA
Wirt: Maus
Monoclonal
1G4
unconjugated
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- Target
- Ethenoadenosine
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Unkonjugiert
- Applikation
- Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)
- Sterilität
- 0.2 μm filtered
- Klon
- 1G4
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- Applikationshinweise
- For immunohistology, flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- Haltbarkeit
- 12 months
-
- Target
- Ethenoadenosine
- Substanzklasse
- Chemical
- Hintergrund
- The reaction of chloroacetaldehyde (CAA) with DNA results in the formation of ethenoadenosine also known as 1,N6-ethenodeoxy-adenosine or etheno-A. CAA is formed through metabolization of for example vinyl chloride, a well established carcinogen. In RNA, after in vitro activation, etheno-A and etheno-C are the principle products of RNA damage. Etheno derivate formation may be highest in single-stranded DNA- regions. The monoclonal antibody 1G4 reacts with both the ribose and deoxyribose form of the adduct. The antibody is not cross reactive with non-modified DNA or the normal nucleotides.
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