VIPR1 Antikörper (AA 151-250) (Alexa Fluor 350)

Produktnummer ABIN2178783

Produktdetails anti-VIPR1 Antikörper (Alexa Fluor 350)

Target: VIPR1 (Vasoactive Intestinal Peptide Receptor 1 (VIPR1))

Bindungsspezifität: AA 151-250

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VIPR1 Antikörper ist konjugiert mit Alexa Fluor 350

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GPCR RDC1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu VIPR1

Target: VIPR1 (Vasoactive Intestinal Peptide Receptor 1 (VIPR1))

Andere Bezeichnung: Rdc1 (VIPR1 Produkte)

Synonyme: HVR1 antikoerper, II antikoerper, PACAP-R-2 antikoerper, PACAP-R2 antikoerper, RDC1 antikoerper, V1RG antikoerper, VAPC1 antikoerper, VIP-R-1 antikoerper, VIPR antikoerper, VIRG antikoerper, VPAC1 antikoerper, VPAC1R antikoerper, VPCAP1R antikoerper, CVIPR antikoerper, AV071699 antikoerper, VIP-R1 antikoerper, RATVASREC antikoerper, VASREC antikoerper, VIPR1 antikoerper, LOC100226500 antikoerper, vipr1 antikoerper, hvr1 antikoerper, rdc1 antikoerper, v1rg antikoerper, vipr antikoerper, virg antikoerper, vapc1 antikoerper, vpac1 antikoerper, vpcap1 antikoerper, vpac1-r antikoerper, VIP-R antikoerper, vasoactive intestinal peptide receptor 1 antikoerper, vasoactive intestinal peptide receptor 1b antikoerper, vasoactive intestinal peptide receptor 1 S homeolog antikoerper, vasoactive intestinal polypeptide receptor antikoerper, VIPR1 antikoerper, Vipr1 antikoerper, vipr1b antikoerper, vipr1 antikoerper, vipr1.S antikoerper, LOC100303683 antikoerper

Hintergrund:

Synonyms: C-X-C chemokine receptor type 7, Chemokine orphan receptor 1, CMKOR1, CXC-R7, CXCR-7, CXCR7, G-protein coupled receptor 159, G-protein coupled receptor RDC1 homolog, GPR159, RDC-1, RDC1, CXCR7_HUMAN, ACKR3

Background: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates

Gen-ID: 57007

UniProt: P25106