CD300a Antikörper
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- Target Alle CD300a (CD300A) Antikörper anzeigen
- CD300a (CD300A)
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CD300a Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Flow Cytometry (FACS)
- Spezifität
- Recognizes human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), a 60kD transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.
- Aufreinigung
- Protein A purified
- Immunogen
- Human HPB acute lymphoid leukaemia cell line.
- Klon
- MEM-260
- Isotyp
- IgG1
- Top Product
- Discover our top product CD300A Primärantikörper
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- Applikationshinweise
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Approved: Flo, WB
Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request. Western Blot: LS-C45034 detects a band of approximately 60kD in HPB cell lysates under non-reducing conditions. - Kommentare
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Target Species of Antibody: Human
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- PBS, pH 7.4, 0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- Target
- CD300a (CD300A)
- Andere Bezeichnung
- CD300A (CD300A Produkte)
- Synonyme
- CD300L-B1 antikoerper, CD300A antikoerper, clm8 antikoerper, B230315M08Rik antikoerper, Clm8 antikoerper, LMIR1 antikoerper, MAIR-I antikoerper, MAIR-Ia antikoerper, MMAC8 antikoerper, Pigr4 antikoerper, mcpir1 antikoerper, CLM-8 antikoerper, CMRF-35-H9 antikoerper, CMRF-35H antikoerper, CMRF35-H antikoerper, CMRF35-H9 antikoerper, CMRF35H antikoerper, CMRF35H9 antikoerper, IGSF12 antikoerper, IRC1 antikoerper, IRC1/IRC2 antikoerper, IRC2 antikoerper, IRp60 antikoerper, CD300 molecule like family member g antikoerper, CD300a molecule antikoerper, CMRF35-like molecule 8 antikoerper, CD300A molecule antikoerper, Cd300a molecule antikoerper, CD300LG antikoerper, CD300A antikoerper, LOC483289 antikoerper, clm8 antikoerper, Cd300a antikoerper
- Hintergrund
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Name/Gene ID: CD300A
Synonyms: CD300A, CD300a antigen, CD300a molecule, CMRF35-like molecule 8, CMRF35-H, CMRF35-H9, CLM-8, CMRF35H9, IGSF12, Inhibitory receptor protein 60, IRC2, IRC1, NK inhibitory receptor, CMRF-35-H9, CMRF-35H, CMRF35H, IRC1a, IRp60, Leukocyte membrane antigen - Gen-ID
- 11314
- UniProt
- Q9UGN4
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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