PDGF-BB Homodimer Antikörper

Produktnummer ABIN205942

Produktdetails

Target: PDGF-BB Homodimer

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), ELISA, Functional Studies (Func)

Spezifität: Recognizes human PDGF-BB (Platelet derived growth factor B chain), a disulphide-linked beta-chain homodimer and member of the PDGF family, released from platelet alpha-granules following trauma/platelet activation. Naturally occurring active forms of PDGF exist as dimers of two alpha chains (AA), two beta chains (BB), or a combination of both chains (AB), all of which signal through the high-affinity PDGF-Ralpha receptor, and the latter two of which can also signal through the PDGF-Rbeta receptor. PDGFs are potent mitogens for a variety of cells including those of the connective tissue, bone and cartilage, blood and smooth muscle cells, and are involved in several biological processes including chemotaxis, hyperplasia and embryonic neurogenesis. The expression of PDGF-BB is associated with autocrine growth stimulation and the formation of various tumor types, with several studies focusing on dermatofibrosarcoma protuberans (DP), an infiltrating skin tumor arising from a translocation occurring between chromosome 22 (the location of the PDGFB gene) and chromosome 17 (the location of the COL1A1 gene), which results in the generation of the COL1A1-PDGFB chimeric protein.

Aufreinigung: Purified

Immunogen: Recombinant human PDGF-BB.

Type of Immunogen: Recombinant protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Approved: ELISA (0.5 μg/mL), Func (3 - 4 μg/mL), WB (0.1 - 0.2 μg/mL)

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Distilled Water. For long term storage the addition of 0.09 % sodium azide is recommended. For functional studies do not add azide.

Konzentration: Lot specific

Buffer: Lyophilized, PBS,  pH 7.4.

Antigendetails

Target: PDGF-BB Homodimer

Andere Bezeichnung: PDGF-BB

Synonyme: PDGF-2 antikoerper, PDGF2 antikoerper, SIS antikoerper, SSV antikoerper, c-sis antikoerper, PDGF-B antikoerper, Sis antikoerper, platelet derived growth factor subunit B antikoerper, platelet derived growth factor, B polypeptide antikoerper, PDGFB antikoerper, Pdgfb antikoerper

Hintergrund: Name/Gene ID: PDGFB
Family: PDGF

Synonyms: PDGFB, Becaplermin, PDGF-BB, PDGF-b, SSV, PDGF subunit B, PDGF-2, PDGF2, Proto-oncogene c-Sis, SIS, C-sis, PDGF, B chain

Gen-ID: 5155