CCR3 Antikörper (C-Term)

Produktnummer ABIN205726

Produktdetails anti-CCR3 Antikörper

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: Recognizes human CD193, otherwise known as CC chemokine receptor 3 (CCR3), a seven-helix transmembrane G-protein coupled receptor which, along with and, acts as a principal receptor for the fusion and entry of HIV into target cells. CD193 is expressed by eosinophils, basophils, mast cells, microglia, Th2 helper cells and some epithelial cells. CD193 acts as a receptor for several CC chemokines including monocyte chemoattractant proteins (MCP) -1, -2, -3 and -4, MIP-1a, MIP-1AY, and RANTES. The eotaxin subgroup of CC chemokines act as specific agonists for CD193, and this interaction has become a focus area for studies into the infection of microglia by HIV and allergy research. Has been used successfully for the detection of human CD193 by immunohistochemistry on formalin fixed, paraffin embedded intervertebral disc tissue.

Aufreinigung: Purified

Immunogen: Synthetic peptide corresponding to a 14 amino acid sequence located near human CD193 carboxy-terminus.

Type of Immunogen: Synthetic peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Approved: IHC, IHC-P (10 μg/mL), WB (1 μg/mL)

Usage: Western Blot: LS-C42330 detects a band of approximately 55kD in human spleen cell lysates (predicted MW. 41kD).

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS, 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: avoid freeze thaw cycles. Store undiluted.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.

Details zu CCR3

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Andere Bezeichnung: CCR3 (CCR3 Produkte)

Synonyme: CC-CKR-3 antikoerper, CD193 antikoerper, CKR3 antikoerper, CMKBR3 antikoerper, CC-CKR3 antikoerper, Cmkbr1l2 antikoerper, Cmkbr3 antikoerper, C-C motif chemokine receptor 3 antikoerper, chemokine (C-C motif) receptor 3 antikoerper, CCR3 antikoerper, Ccr3 antikoerper

Hintergrund: Name/Gene ID: CCR3
Subfamily: Chemokine
Family: GPCR

Synonyms: CCR3, C-C chemokine receptor type 3, B-chemokine receptor, CD193, CD193 antigen, Chemokine c-c motif receptor 3, C-C chemokine receptor 3, CKR3, CC-CKR-3, CCR-3, CMKBR3, Eosinophil eotaxin receptor, Eotaxin receptor, C-C CKR-3, CC chemokine receptor 3

Gen-ID: 1232

UniProt: P51677