CNTNAP2 Antikörper (C-Term)

Produktnummer ABIN2017587

Produktdetails anti-CNTNAP2 Antikörper

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CNTNAP2 Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Spezifität: Rabbit Anti-Caspr2 Polyclonal Antibody detects endogenous levels of mouse and rat Caspr2.

Kreuzreaktivität: Maus, Ratte (Rattus)

Kreuzreaktivität (Details): It is predicted to react with human Caspr2 according to sequence homology.
This product has not been tested for other species yet.

Produktmerkmale: Rabbit Anti-Caspr2 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human Caspr2 (Swiss Prot: Q9UHC6).

Aufreinigung: Immunoaffinity chromatography

Immunogen: KLH-coupled synthetic peptide from C-terminal of human Caspr2.

Isotyp: IgG

Anwendungsinformationen

Kommentare:

Positive Control: mouse brain and rat brain.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/mL.

Konzentration: 0.5 mg/mL

Buffer: Lyophilized with PBS, pH 7.4, containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below.

Referenzen für anti-CNTNAP2 Antikörper (ABIN2017587)

Chen, Koopmans, Gordon, Paliukhovich, Klaassen, van der Schors, Peles, Verhage, Smit, Li: "Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes." in: Biochimica et biophysica acta, Vol. 1854, Issue 7, pp. 827-33, (2015) (PubMed).

Details zu CNTNAP2

Target: CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))

Andere Bezeichnung: Caspr2 (CNTNAP2 Produkte)

Synonyme: AUTS15 antikoerper, CASPR2 antikoerper, CDFE antikoerper, NRXN4 antikoerper, PTHSL1 antikoerper, 5430425M22Rik antikoerper, Caspr2 antikoerper, mKIAA0868 antikoerper, CASPR antikoerper, MGC145769 antikoerper, MGC147944 antikoerper, MGC147981 antikoerper, contactin associated protein like 2 antikoerper, contactin associated protein-like 2 antikoerper, contactin associated protein like 2b antikoerper, CNTNAP2 antikoerper, Cntnap2 antikoerper, cntnap2b antikoerper, cntnap2 antikoerper

Hintergrund: Contacting-associated protein 2 (Caspr2) is a member of the neurexin superfamily that mediates nervous system cell-cell interactions. The C-terminal region of Caspr2 participates in the association with Kv1.1, Kv1.2 and their Kv-beta-2 subunit. Expression of Caspr2 is regulated directly by transcription factor FOXP2. Disruption or decreased expression of Caspr2 probably leads to a disturbed distribution of potassium channels in the nervous system. Mutations in the Caspr2 gene have been linked to many diseases such as focal epilepsy, autism spectrum disorder and cortical dysplasia-focal epilepsy syndrome (CDFES).

UniProt: Q9UHC6