PAWR Antikörper

Produktnummer ABIN1944911

Produktdetails anti-PAWR Antikörper

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAWR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC: 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C,-20 °C

Referenzen für anti-PAWR Antikörper (ABIN1944911)

Chakraborty, Qiu, Vasudevan, Rangnekar: "Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression." in: Cancer research, Vol. 61, Issue 19, pp. 7255-63, (2001) (PubMed).

Chang, Kim, Shin: "p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition." in: FEBS letters, Vol. 510, Issue 1-2, pp. 57-61, (2001) (PubMed).

Johnstone, See, Sells, Wang, Muthukkumar, Englert, Haber, Licht, Sugrue, Roberts, Rangnekar, Shi: "A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1." in: Molecular and cellular biology, Vol. 16, Issue 12, pp. 6945-56, (1997) (PubMed).

Details zu PAWR

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Abstract: PAWR Produkte

Synonyme: MGC81382 antikoerper, pawrl antikoerper, zgc:103513 antikoerper, PAWR antikoerper, PAR4 antikoerper, Par-4 antikoerper, Par4 antikoerper, 2310001G03Rik antikoerper, pro-apoptotic WT1 regulator antikoerper, PRKC, apoptosis, WT1, regulator L homeolog antikoerper, PRKC, apoptosis, WT1, regulator antikoerper, PAWR antikoerper, pawr.L antikoerper, pawr antikoerper, Pawr antikoerper

Hintergrund: Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Molekulargewicht: 36568 Da

Gen-ID: 5074

UniProt: Q96IZ0