SPG11 Antikörper

Produktnummer ABIN1888237

Produktdetails anti-SPG11 Antikörper

Target: SPG11 (Spastic Paraplegia 11 (Autosomal Recessive) (SPG11))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPG11 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide of human SPG11.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu SPG11

Target: SPG11 (Spastic Paraplegia 11 (Autosomal Recessive) (SPG11))

Andere Bezeichnung: SPG11 (SPG11 Produkte)

Synonyme: 6030465E24Rik antikoerper, A330015I11 antikoerper, C530005A01Rik antikoerper, KIAA1840 antikoerper, RGD1562529 antikoerper, SPG11, spatacsin vesicle trafficking associated antikoerper, Spg11 antikoerper, SPG11 antikoerper

Hintergrund: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.? Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia (cHSP) in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration.Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC.Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage.It is expressed in all structures of the brain, with a high expression in the cerebellum.SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC.Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene.? Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism.
Synonyms: Spastic paraplegia 11, colorectal carcinoma-associated protein, spatacsin