CNOT4 Antikörper (N-Term)

Produktnummer ABIN1888129

Produktdetails anti-CNOT4 Antikörper

Target: CNOT4 (CCR4-NOT Transcription Complex Subunit 4 (CNOT4))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CNOT4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the amino terminus of the human CNOT4.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu CNOT4

Target: CNOT4 (CCR4-NOT Transcription Complex Subunit 4 (CNOT4))

Andere Bezeichnung: CNOT4 (CNOT4 Produkte)

Synonyme: CLONE243 antikoerper, NOT4 antikoerper, NOT4H antikoerper, Not4 antikoerper, Not4h antikoerper, Not4hp antikoerper, CNOT4 antikoerper, CCR4-NOT transcription complex subunit 4 antikoerper, RNA binding (RRM/RBD/RNP motifs) family protein antikoerper, CCR4-NOT transcription complex, subunit 4 antikoerper, CCR4-NOT transcription complex subunit 4 L homeolog antikoerper, CCR4-NOT transcription complex, subunit 4b antikoerper, CNOT4 antikoerper, AT3G45630 antikoerper, Cnot4 antikoerper, cnot4.L antikoerper, cnot4b antikoerper

Hintergrund: CNOT4 is a component of the CCR4-NOT transcription complex, a complex that is implicated in the repression of RNA polymerase II transcription.In the CCR4-NOT complex, CNOT4 acts as an E3 ubiquitin-protein ligase and interacts with a subset of E2 ubiquitin-conjugating enzymes through a unique C4C4 RING domain.This E3 ligase activity was shown to be dependent on the selective and specific interaction with the ubiquitin conjugating enzyme UbcH5B.In yeast, mutations in CNOT4 that prevented its interaction with the UbcH5B homolog UBC4 caused increased sensitivity to hydroxyurea, heat shock, and hygromycin B, suggesting that CNOT4 and UbcH5B are involved in stress response in vivo.Multiple isoforms of CNOT4 are known to exist.
Synonyms: CCR4-NOT transcription complex subunit 4, NOT4, NOT4H

NCBI Accession: NP_037448