TRMT12 Antikörper (N-Term)

Produktnummer ABIN1888127

Produktdetails anti-TRMT12 Antikörper

Target: TRMT12 (tRNA Methyltransferase 12 Homolog (TRMT12))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRMT12 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Kreuzreaktivität (Details): TYW2 antibody is predicted to not cross-react with other TYW protein family members. At least two isoforms of TYW2 are known to exist, this antibody will detect both isoforms

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the amino terminus of human TYW2.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu TRMT12

Target: TRMT12 (tRNA Methyltransferase 12 Homolog (TRMT12))

Andere Bezeichnung: TYW2 (TRMT12 Produkte)

Synonyme: 4632406N01Rik antikoerper, AI449275 antikoerper, Tyw2 antikoerper, TRM12 antikoerper, TYW2 antikoerper, RGD1307127 antikoerper, trmt12 antikoerper, tRNA methyltranferase 12 antikoerper, tRNA methyltransferase 12 homolog antikoerper, tRNA methyltransferase 12 antikoerper, tRNA methyltransferase 12 homolog (S. cerevisiae) antikoerper, Trmt12 antikoerper, TRMT12 antikoerper, trmt12 antikoerper

Hintergrund: TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway.Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome.TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation.TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.
Synonyms: TYW2, Radical S-adenosyl methionine and flavodoxin domain-containing protein 2, tRNA wybutosine-synthesizing protein 2 homolog, TRM12, TRMT12

UniProt: Q53H54