ATP2C2 Antikörper (N-Term)

Produktnummer ABIN1888109

Produktdetails anti-ATP2C2 Antikörper

Target: ATP2C2 (ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATP2C2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Kreuzreaktivität (Details): At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the amino terminus of human ATP2C2.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu ATP2C2

Target: ATP2C2 (ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2))

Andere Bezeichnung: ATP2C2 (ATP2C2 Produkte)

Synonyme: KIAA0703 antikoerper, MGC146612 antikoerper, SPCA2 antikoerper, 1810010G06Rik antikoerper, Spca2 antikoerper, mKIAA0703 antikoerper, ATPase secretory pathway Ca2+ transporting 2 antikoerper, ATPase, Ca++ transporting, type 2C, member 2 S homeolog antikoerper, ATPase, Ca++ transporting, type 2C, member 2 antikoerper, ATP2C2 antikoerper, atp2c2.S antikoerper, atp2c2 antikoerper, Atp2c2 antikoerper

Hintergrund: ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases.This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen.Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles.Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation.Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
Synonyms: Calcium-transporting ATPase type 2C member 2, PMR1, SPCA2, hSPCA2

NCBI Accession: NP_055676

Pathways: Ribonucleoside Biosynthetic Process