SIPA1L1 Antikörper (N-Term)

Produktnummer ABIN1887972

Produktdetails anti-SIPA1L1 Antikörper

Target: SIPA1L1 (Signal-Induced Proliferation-Associated 1 Like 1 (SIPA1L1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIPA1L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide from near the amino terminus of human SIPA1L1.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu SIPA1L1

Target: SIPA1L1 (Signal-Induced Proliferation-Associated 1 Like 1 (SIPA1L1))

Andere Bezeichnung: SIPA1L1 (SIPA1L1 Produkte)

Synonyme: 4931426N11Rik antikoerper, AW213287 antikoerper, Spar antikoerper, mKIAA0440 antikoerper, SPAL antikoerper, Spa-1 antikoerper, Spa1 antikoerper, E6TP1 antikoerper, cb600 antikoerper, id:ibd5092 antikoerper, sb:cb600 antikoerper, si:ch211-106p8.1 antikoerper, wu:fc43g06 antikoerper, signal induced proliferation associated 1 like 1 antikoerper, signal-induced proliferation-associated 1 like 1 antikoerper, SIPA1L1 antikoerper, sipa1l1 antikoerper, Sipa1l1 antikoerper

Hintergrund: Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs.SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses.Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1.CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
Synonyms: Signal-induced proliferation associated-like protein 1, E6TP1

NCBI Accession: NP_056371