SKI Antikörper (N-Term)

Produktnummer ABIN1887862

Produktdetails anti-SKI Antikörper

Target: SKI (SKI Proto-Oncogene (SKI))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKI Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide from near the amino terminus of human Ski.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu SKI

Target: SKI (SKI Proto-Oncogene (SKI))

Andere Bezeichnung: Ski (SKI Produkte)

Synonyme: SGS antikoerper, SKV antikoerper, SKI antikoerper, C-SKI antikoerper, RGD1565591 antikoerper, c-ski antikoerper, 2310012I02Rik antikoerper, 2610001A11Rik antikoerper, AA062172 antikoerper, AA589460 antikoerper, BC004088 antikoerper, ski antikoerper, skv antikoerper, xski antikoerper, id:ibd1250 antikoerper, SKI proto-oncogene antikoerper, ski sarcoma viral oncogene homolog (avian) antikoerper, SKI proto-oncogene L homeolog antikoerper, v-ski avian sarcoma viral oncogene homolog a antikoerper, SKI antikoerper, Ski antikoerper, ski.L antikoerper, skia antikoerper

Hintergrund: TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis.This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN.Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes.Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
Synonyms: c-ski, v-ski sarcoma viral oncogene homolog

UniProt: P12755

Pathways: Stem Cell Maintenance, Tube Formation, Skeletal Muscle Fiber Development