BAG1 Antikörper (N-Term)

Produktnummer ABIN1887852

Produktdetails anti-BAG1 Antikörper

Target: BAG1 (BCL2-Associated Athanogene (BAG1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide from near the amino terminus of human BAG-1.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu BAG1

Target: BAG1 (BCL2-Associated Athanogene (BAG1))

Andere Bezeichnung: BAG-1 (BAG1 Produkte)

Synonyme: BAG-1 antikoerper, HAP antikoerper, RAP46 antikoerper, Rap46 antikoerper, Bag-1 antikoerper, ATBAG1 antikoerper, BCL-2-associated athanogene 1 antikoerper, MSG15.15 antikoerper, MSG15_15 antikoerper, im:7148830 antikoerper, si:dkey-216e9.4 antikoerper, BCL2 associated athanogene 1 antikoerper, putative bcl2-associated athanogene antikoerper, BCL2-associated athanogene 1 antikoerper, Bcl2 associated athanogene 1 antikoerper, BAG family molecular chaperone regulator 1 antikoerper, BCL-2-associated athanogene 1 antikoerper, BAG1 antikoerper, Smp_005900 antikoerper, Bag1 antikoerper, bag-1 antikoerper, LOC781741 antikoerper, bag1 antikoerper

Hintergrund: Bcl-2-associated athanogene 1 (BAG-1) was first identified as an anti-apoptotic bcl-2-binding protein.Later it was found to bind the molecular chaperones Hsp70 and Hsc70 through its carboxy-terminal sequence (termed the Bag domain), resulting in the inhibition of the refolding activity of these chaperones.It is thought that by binding and inhibiting these molecular chaperones, BAG-1is able to modulate the expression level of proteins requiring chaperones to fold correctly.One such group of proteins that are affected is glucocorticoid receptors.Other reports have suggested that the level of BAG-1 expression correlates with the aggressiveness of various cancers.Multiple isoforms of BAG-1 are known to exist.
Synonyms: Bcl-2-binding athanogene-1, receptor-associated protein 46, RAP46

NCBI Accession: NP_004314