FRMPD4 Antikörper (Center)

Produktnummer ABIN1887749

Produktdetails anti-FRMPD4 Antikörper

Target: FRMPD4 (FERM and PDZ Domain Containing 4 (FRMPD4))

Bindungsspezifität: Center

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FRMPD4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: FRMPD4 antibody was raised against an 18 amino acid peptide from near the center of human FRMPD4.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu FRMPD4

Target: FRMPD4 (FERM and PDZ Domain Containing 4 (FRMPD4))

Andere Bezeichnung: FRMPD4 (FRMPD4 Produkte)

Synonyme: RGD1566031 antikoerper, PDZD10 antikoerper, PDZK10 antikoerper, Gm196 antikoerper, PKAP1 antikoerper, Pdzd10 antikoerper, Pdzk10 antikoerper, Preso1 antikoerper, FERM and PDZ domain containing 4 antikoerper, Frmpd4 antikoerper, FRMPD4 antikoerper, frmpd4 antikoerper

Hintergrund: The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain.FRMPD4, also known as Preso, also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus.It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions.Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width, conversely, knockdown experiments using RNAi caused a decrease in spine density, indicating FRMPD4 positively regulates dendritic spine density but not morphology.The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission, suggesting that FRMPD4 is required for maintenance of excitatory synaptic transmission.
Synonyms: FERM and PDZ domain-containing 4, Preso, PDZD10, PDZK10

NCBI Accession: NP_055553