MED28 Antikörper (Center)

Produktnummer ABIN1887640

Produktdetails anti-MED28 Antikörper

Target: MED28 (Mediator Complex Subunit 28 (MED28))

Bindungsspezifität: Center

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MED28 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide from near the center of human MED28.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu MED28

Target: MED28 (Mediator Complex Subunit 28 (MED28))

Andere Bezeichnung: MED28 (MED28 Produkte)

Synonyme: 1500003D12Rik antikoerper, EG1 antikoerper, magicin antikoerper, Eg1 antikoerper, FKSG20 antikoerper, RGD1305875 antikoerper, wu:fc74b11 antikoerper, zgc:103633 antikoerper, AI451633 antikoerper, AU045690 antikoerper, mediator complex subunit 28 antikoerper, MED28 antikoerper, Med28 antikoerper, med28 antikoerper

Hintergrund: The mediator complex is a multi-protein transcriptional co-activator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factor.One of the proteins in this complex is MED28, also known as Magicin.MED28 is expressed in many cell lines and tissues.It has been shown that a down-regulation of MED28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell differentiation and conversely its over-expression represses expression of SMC genes.MED28 can also form a ternary complex with Grb2 and Merlin, the neurofibromatosis 2 tumor suppressor protein, indicating that MED28 may play a role in Merlin's tumor suppressive activity.MED28 has also been recently identified as an HIV dependency factor (HDF), suggesting that MED28 may be an important drug target in HIV treatment.At least two isoforms of MED28 are known to exist.
Synonyms: Mediator of RNA polymerase II transcription subunit 28, magicin, EG1

NCBI Accession: NP_079481

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation