Syntaphilin Antikörper (Center)

Produktnummer ABIN1887607

Produktdetails anti-Syntaphilin Antikörper

Target: Syntaphilin (SNPH)

Bindungsspezifität: Center

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Syntaphilin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide from near the center of human Syntaphilin.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu Syntaphilin

Target: Syntaphilin (SNPH)

Andere Bezeichnung: Syntaphilin (SNPH Produkte)

Synonyme: bA314N13.5 antikoerper, 6430515A01 antikoerper, AW045671 antikoerper, AW556958 antikoerper, AW743098 antikoerper, mKIAA0374 antikoerper, syntaphilin antikoerper, SNPH antikoerper, Snph antikoerper

Hintergrund: Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait.Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25.Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis.Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis.Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria.This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function.Multiple isoforms are known to exist.
Synonyms: SNPH

UniProt: O15079

Pathways: Synaptic Vesicle Exocytosis