PTRH2 Antikörper (Center)

Produktnummer ABIN1887581

Produktdetails anti-PTRH2 Antikörper

Target: PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))

Bindungsspezifität: Center

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTRH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide from near the center of human Bit1.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu PTRH2

Target: PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))

Andere Bezeichnung: Bit1 (PTRH2 Produkte)

Synonyme: BIT1 antikoerper, PTH2 antikoerper, A230072I16Rik antikoerper, Bit1 antikoerper, CGI-147 antikoerper, wu:fj09f02 antikoerper, zgc:109954 antikoerper, RGD1306819 antikoerper, peptidyl-tRNA hydrolase 2 antikoerper, ptrh2 antikoerper, CC1G_10259 antikoerper, ANI_1_1036184 antikoerper, AOR_1_2082154 antikoerper, PTRH2 antikoerper, Ptrh2 antikoerper

Hintergrund: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading.Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment.Bit1 (Bcl-2 inhibitor of transcription 1) was recently identified as being involved in this process.Bit1 is a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis.Both AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination.It has been suggested that Bit1-AES complexes turn off a survival-promoting gene transcription program controlled by TLE.Interestingly, apoptosis of cells transfected with Bit1 and AES could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.
Synonyms: Bcl-2 inhibitor of transcription 1, Peptidyl-tRNA hydrolase 2

NCBI Accession: NP_057161