IRF8 Antikörper (C-Term)

Produktnummer ABIN1887385

Produktdetails anti-IRF8 Antikörper

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRF8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to 16 amino acids near the carboxy terminus of human IRF8.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu IRF8

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Andere Bezeichnung: IRF8 (IRF8 Produkte)

Synonyme: zgc:92252 antikoerper, IRF8 antikoerper, MGC140338 antikoerper, DKFZp469B0320 antikoerper, H-ICSBP antikoerper, ICSBP antikoerper, ICSBP1 antikoerper, IRF-8 antikoerper, icsbp1 antikoerper, AI893568 antikoerper, Icsbp1 antikoerper, Myls antikoerper, interferon regulatory factor 8 antikoerper, interferon regulatory factor 8 L homeolog antikoerper, irf8 antikoerper, IRF8 antikoerper, irf8.L antikoerper, Irf8 antikoerper

Hintergrund: Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms.During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes.Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases, but IRF8 mediates activation of NF-kappaB by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells.Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia.

NCBI Accession: NP_002154

Pathways: Cellular Response to Molecule of Bacterial Origin