FERMT3 Antikörper (C-Term)

Produktnummer ABIN1887294

Produktdetails anti-FERMT3 Antikörper

Target: FERMT3 (Fermitin Family Member 3 (FERMT3))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FERMT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the carboxy terminus of the human KINDLIN3.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu FERMT3

Target: FERMT3 (Fermitin Family Member 3 (FERMT3))

Andere Bezeichnung: KINDLIN3 (FERMT3 Produkte)

Synonyme: C79673 antikoerper, Kindlin3 antikoerper, RGD1310168 antikoerper, MGC69069 antikoerper, MGC88900 antikoerper, KIND3 antikoerper, MIG-2 antikoerper, MIG2B antikoerper, UNC112C antikoerper, URP2 antikoerper, URP2SF antikoerper, zgc:64101 antikoerper, fermitin family member 3 antikoerper, fermitin family member 3 L homeolog antikoerper, fermitin family member 3b antikoerper, Fermt3 antikoerper, fermt3.L antikoerper, fermt3 antikoerper, FERMT3 antikoerper, fermt3b antikoerper

Hintergrund: The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites.The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain.KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading.In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets.Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer.A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.
Synonyms: Fermitin family homolog 3, FERMT, Unc-112-related protein 2, MIG2-like protein, KIND3, MIG2B, URP2

NCBI Accession: NP_848537